大腸潰瘍部に残存する上皮細胞隗は幹細胞特性を維持

大腸炎モデルの難治性潰瘍部に上皮細胞隗が残存することを見出し、それらは陰窩幹細胞・娘細胞の特徴（Lgr5, Sox9. Dll1, Bmi4をヘテロには発現）を維持していることを明らかにしました。これらの上皮細胞隗は、難治性潰瘍部にも関わらず、粘膜再生ポテンシャルを維持する特殊な細胞集団と推察されます。We found that epithelial cell remnants remain in the intractable ulcerated areas of the colitis model and clarified that they maintain the characteristics of crypt stem cells and daughter cells (heterogeneous expression of Lgr5, Sox9, Dll1, and Bmi4). These epithelial cell remnants are thought to be a special cell population that maintains mucosal regeneration potential despite the intractable ulcerated areas. Please see "Ectopically Localized Epithelial Cell Clumps in Ulcers Are Derived from Reserved Crypt Stem Cells in a Mouse Model of Ulcerative Colitis | Digestive Diseases and Sciences".